Brown, L.M., Hagenson, R.A., Sheltzer, J.M. (2023). An elevated rate of whole-genome duplication events in cancers from Black patients. medRxiv. doi:10.1101/2023.11.10.23298349.

Bhattacharjee, D., Bakar, J., Chitnis, S.P., Sausville, E.L., Ashtekar, K.D., Mendelson, B.E., Long, K., Smith, J.C., Heppner, D.E., Sheltzer, J.M. (2023). Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor. Cell Chemical Biology. doi:10.1016/j.chembiol.2023.09.013.

Lakhani, A.A., Thompson, S.L., Sheltzer, J.M. (2023). Aneuploidy in human cancer: new tools and perspectives. Trends in Genetics. doi:10.1016/j.tig.2023.09.002.

Girish, V., Lakhani, A.A., Thompson, S.L., Scaduto, C.M., Brown, L.M., Hagenson, R.A., Sausville, E.L., Mendelson, B.E., Kandikuppa, P.K., Lukow, D.A., Yuan, M.L., Stevens, E.C., Lee, S.N., Schukken, K.M., Akalu, S.M., Vasudevan, A., Zou, C., Salovska, B., Li, W., Smith, J.C., Taylor, A.M., Martienssen, R.A., Liu, Y., Sun, R., Sheltzer, J.M. (2023). Oncogene-like addiction to aneuploidy in human cancers. Science. doi:10.1126/science.adg4521.

Schukken, K.M., and Sheltzer, J.M. (2022). Extensive protein dosage compensation in aneuploid human cancers. Genome Research. doi.org/10.1101/gr.276378.121.

Smith, J.C., and Sheltzer, J.M. (2022). Genome-wide identification and analysis of prognostic features in human cancers. Cell Reports. doi.org/10.1016/j.celrep.2022.110569.

Ghosh, A., Girish, V., Yuan, M.L., Coakley, R.D., Alexis, N.E., Sausville, E.L., Vasudevan, A., Chait, A.R., Sheltzer, J.M.*, Tarran, R.* (2022). Combustible and electronic cigarette exposures increase ACE2 activity and SARS-CoV-2 Spike binding. AJRCCM. doi: 10.1164/rccm.202106-1377LE.

Lukow, D.A., Sausville, E.L., Suri, P., Chunduri, N.K., Wieland, A., Leu, J., Smith, J.C., Girish, V., Kumar, A.A., Kendall, J., Wang, Z., Storchova, Z., Sheltzer, J.M. (2021). Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies. Developmental Cell. doi.org/10.1016/j.devcel.2021.07.009

Vasudevan, A., Schukken, K.M., Sausville, E.L., Girish, V., Adebambo, O.A., Sheltzer, J.M. (2021). Aneuploidy as a promoter and suppressor of malignant growth. Nature Reviews Cancer doi.org/10.1038/s41568-020-00321-1.

Hoffmann M., Hofmann-Winkler H., Smith J.C., Krüger N., Arora P., Sørensen L.K., Søgaard O.S., Hasselstrøm J.B., Winkler M., Hempel T., Raich L., Olsson S., Danov O., Jonigk D., Yamazoe T., Yamatsuta K., Mizuno H., Ludwig S., Noé F., Kjolby M., Braun A., Sheltzer J.M., Pöhlmann S. (2021). Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity. EBioMedicine. 65, 103255.

Girish, V. and Sheltzer, J.M. (2020). A CRISPR Competition Assay to Identify Cancer Genetic Dependencies. Bio-protocol. doi:10.21769/BioProtoc.3682.

Lin, A., Sheltzer, J.M. (2020). Discovering and validating cancer genetic dependencies: approaches and pitfalls. Nature Reviews Genetics doi.org/10.1038/s41576-020-0247-7.

Smith, J.C., Sausville, E.L., Girish, V., Yuan, M.L., John, K.M., and Sheltzer, J.M. (2020). Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract. Developmental Cell doi.org/10.1016/j.devcel.2020.05.012.  

Vasudevan, A., Baruah, P.S., Smith, J.C., Wang, Z., Sayles, N.M., Andrews, P., Kendall, J., Leu, J., Chunduri, N.K., Levy, D., Wigler, M., Storchova, Z., Sheltzer, J.M. (2020). Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer. Developmental Cell 52, 413-428.e6.   

Lin, A., Giuliano, C.J., Palladino, A., John, K.M., Abramowicz, C., Yuan, M.L., Sausville, E.L., Lukow, D.A., Luwei, L., Chait, A.R., Galluzzo., Z.C., Tucker, C., Sheltzer, J.M. (2019). Off-target toxicity is a common mechanism-of-action of cancer drugs undergoing clinical trials. Science Translational Medicine 11, eaaw8412.

Giuliano, C.G., Lin, A., Girish, V., Sheltzer, J.M. (2019). Generating Single Cell–Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9. Current Protocols in Molecular Biology 128:e100.

Smith, J.C., Sheltzer, J.M. (2018) Systematic identification of mutations and copy number alterations associated with cancer patient prognosis. eLife e39217.

Sheltzer, J.M. (2018) Gender disparities among independent fellows in biomedical research. Nature Biotechnology 36, 1018–1021.

Giuliano, C.J., Lin, A., Smith, J.C., Palladino, A.C., and Sheltzer, J.M. (2018) MELK expressed correlates with tumor mitotic activity but is not required for cancer growth. eLife 7:e32838.

Lin, A., Giuliano, C.J., Sayles, N.M., and Sheltzer, J.M. (2017) CRISPR/Cas9 mutagenesis invalidates a putative cancer dependency targeted in on-going clinical trials. eLife 6:e24179.

Sheltzer, J.M., Ko, J.C., Replogle, J.M., et al. (2017) Single-chromosome gains commonly function as tumor suppressors.  Cancer Cell 31, 1-16.

Sheltzer, J. M., Smith, J. C. (2014) Elite male faculty in the life sciences employ fewer women. Proc Natl Acad Sci 111 (28).

Sheltzer, J. M. (2013) A transcriptional and metabolic signature of primary aneuploidy is present in chromosomally unstable cancer cells and informs clinical prognosis. Cancer Res 73 (21).

Sheltzer, J. M. and Torres, E. M. and Dunham, M. J. and Amon, A. (2012) Transcriptional consequences of aneuploidy. Proc Natl Acad Sci 109 (31).

Sheltzer, J. M. and Amon, A. (2011) The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet 27 (11).

Sheltzer, J. M. and Blank, H. M. and Pfau, S. J. and Tange, Y. and George, B. M. and Humpton, T. J. and Brito, I. L. and Hiraoka, Y. and Niwa, O. and Amon, A. (2011) Aneuploidy drives genomic instability in yeast. Science 333 (6045).

Sheltzer, J.M. and Rose, M.D. (2009) The class V myosin Myo2p is required for Fus2p transport and actin polarization during the yeast mating response. Mol. Biol. Cell 20 (2909).